Parts of her traumatic childhood came to light in her 2026 memoir You With the Sad Eyes. She described it as the story of “a little girl with sad eyes who became Christina Applegate. She still has those sad eyes—but she’s stronger, resilient, and different.”
Personal Challenges
After her 2021 multiple sclerosis (MS) diagnosis, she stepped back from on-screen work but continued voice acting. By 2026, pain from MS left her mostly bedridden. Daily routines with her 15-year-old daughter, Sadie, are especially challenging, as she must drive her to school and activities while managing her illness.
“I want to take her; it’s my favorite thing to do. It’s the only time we have together alone,” she shared. “I tell myself, ‘Get her there safely and back to bed.’ That’s what I do.”
Philanthropy & Advocacy
Beyond acting, Applegate supports causes like the Entertainment Industry Foundation, Adopt-A-Classroom, The Motion Picture and Television Fund Foundation, World Animal Protection, and the Trevor Project.
She has also been active in breast cancer awareness, serving as a spokesperson for Lee National Denim Day and appearing on Stand Up to Cancer. Her upcoming project, Next in MS, will offer a platform for people living with multiple sclerosis to share their experiences.
Christina Applegate’s story is one of courage, honesty, and resilience. Through her struggles and triumphs, she continues to inspire others, showing the power of perseverance and compassion.
